Mast Cells and Resistance to Immunotherapy in Cancer
Doménico Ribatti
Abstract
Mast cells are involved in tumor growth and their mediators exert both pro- and anti-tumorigenic roles in different human cancers. The identification of defined immunosuppressive pathways that are present in the tumor microenvironment has pointed therapeutic strategies that may promote inflammation and/or innate immune activation in this context. Mast cells can contribute to the immune suppressive tumor microenvironment and may also enhance anti-tumor responses. This review article is focused on the analysis of the mechanisms of the role of mast cells in resistance to immunotherapy in cancer.
Topics & Concepts
Tumor microenvironmentImmunotherapyImmune systemImmunologyMast cellCancer immunotherapyInflammationCancerBiologyCancer researchContext (archaeology)Innate immune systemGeneticsPaleontologyMast cells and histamineImmune Cell Function and InteractionImmunotherapy and Immune Responses