Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers
Bing He, Peng Gao, Yangyang Ding, Chia-Hui Chen, Gregory Chen, Changya Chen, Hannah Kim, Sarah K. Tasian, Stephen P. Hunger, Kai Tan
Abstract
overexpression via enhancer hijacking in B-ALL. We observed a general exclusivity of coding and noncoding mutations affecting the same genes and pathways. We showed that integrated mutation profiles can help define novel patient subtypes with different clinical outcomes. Our study introduces a general strategy to systematically identify and characterize the full spectrum of noncoding mutations in cancers.
Topics & Concepts
TranscriptomeMutationBiologyGeneticsComputational biologyDeregulationGeneBioinformaticsGene expressionMacroeconomicsEconomicsNeuroblastoma Research and TreatmentsGenomics and Chromatin DynamicsCancer Genomics and Diagnostics