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HIV-Resistant and HIV-Specific CAR-Modified CD4+ T Cells Mitigate HIV Disease Progression and Confer CD4+ T Cell Help In Vivo

Colby R. Maldini, Kevin Gayout, Rachel S. Leibman, Derrick L. Dopkin, Joshua Mills, Xiaochuan Shan, Joshua Glover, James L. Riley

2020Molecular Therapy48 citationsDOIOpen Access PDF

Abstract

T cells to engender a functional HIV cure.

Topics & Concepts

CD28BiologyCytotoxic T cellChimeric antigen receptorCD8T cellImmunologyInterleukin 21Immune systemVirologyCancer researchIn vitroBiochemistryCAR-T cell therapy researchImmune Cell Function and InteractionHIV Research and Treatment