Computational and Synthetic approach with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S triple mutant EGFR inhibitors targeting resistance in Non-Small Cell Lung Cancer (NSCLC)
Kshipra S. Karnik, Aniket P. Sarkate, Shailee V. Tiwari, Rajaram Azad, Prasad Burra, Pravin S. Wakte
Topics & Concepts
T790MChemistryProtein Data Bank (RCSB PDB)OsimertinibDocking (animal)StereochemistryIC50EGFR inhibitorsKinaseBiochemistryIn vitroEpidermal growth factor receptorErlotinibReceptorGefitinibNursingMedicineLung Cancer Treatments and MutationsCancer therapeutics and mechanismsQuinazolinone synthesis and applications