Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform
Yan Zhang, Sungho Kim, Weihua Shi, Yaoyao Zhao, Insu Park, Christopher Kenji Brenden, Hrishikesh Iyer, Prasoon Jha, Rashid Bashir, Jonathan V. Sweedler, Yurii A. Vlasov
Abstract
We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis.
Topics & Concepts
MicrofluidicsElectrosprayMaterials scienceAnalyteNanotechnologyElectrospray ionizationExtractive electrospray ionizationSiliconMass spectrometryChipMicrofluidic chipAnalytical Chemistry (journal)ChromatographyChemistryOptoelectronicsComputer scienceProtein mass spectrometryTelecommunicationsInnovative Microfluidic and Catalytic Techniques InnovationMicrofluidic and Capillary Electrophoresis ApplicationsMass Spectrometry Techniques and Applications