Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation
Shuyin Bao, Xiuzhi Wang, Qianqian Ma, Cheng‐Xi Wei, Ji‐Xing Nan, Wuliji Ao
Abstract
), etc. Principles of Mongolian medicine in treating diseases: by balancing "three essences or roots" and "seven elements", strengthening liver and kidney function, transporting nutrients to enhance physical strength and disease resistance, and combined with drugs for comprehensive conditioning treatment. However, their molecular mechanisms remain unclear. In this review, we prospect that Mongolian medicines might be a promising treatment for T2DM-NAFLD by activating P2X7R/NLRP3/NF-κB inflammatory pathway via lipid-sensitive nuclear receptors (i.e., FXR and LXR).
Topics & Concepts
Traditional medicineTerminalia chebulaCassiaGardenia jasminoidesCoptis chinensisMedicineNonalcoholic fatty liver diseasePaeonia lactifloraFatty liverBiologyInternal medicineTraditional Chinese medicinePathologyDiseaseAlternative medicineLiver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseCholesterol and Lipid Metabolism