Photoinduced Decarboxylative C3–H Alkylation of Quinoxalin-2(1<i>H</i>)-ones
Akash Bisoyi, Alisha Rani Tripathy, Girish Suresh Yedase, Shifana Sinu P, Udita Choudhury, Veera Reddy Yatham
Abstract
An efficient, catalyst- and additive-free, visible-light-driven radical C3–H alkylation of quinoxalin-2(1 H )-one derivatives has been developed. This reaction utilizes alkyl-NHP-esters as an alkyl radical donor and quinoxalin-2(1 H )-one derivatives as an alkyl radical acceptor. The operationally simple protocol works under mild reaction conditions and tolerates a variety of functional groups. Furthermore, the synthetic utility of the methodology was successfully implemented for synthesizing biologically relevant C3-alkyl substituted quinoxalin-2(1 H )-one derivatives
Topics & Concepts
AlkylationAlkylChemistryCatalysisReaction conditionsMedicinal chemistryCombinatorial chemistryFunctional groupOrganic chemistryPolymerRadical Photochemical ReactionsSynthesis and Biological EvaluationCO2 Reduction Techniques and Catalysts