The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
Shu Yang, Yingbiao Zhang, Chun‐Yuan Ting, Lucia Bettedi, Kuikwon Kim, Elena Ghaniam, Mary A. Lilly
Topics & Concepts
BiologySmall GTPaseGTPaseCell biologymTORC1RegulatorAmino acidGrowth factorPhosphorylationCytosolTSC2GTPase-activating proteinSignal transductionGuanine nucleotide exchange factorBiochemistryPI3K/AKT/mTOR pathwayReceptorGeneG proteinEnzymePI3K/AKT/mTOR signaling in cancerCellular transport and secretionMast cells and histamine