Radical-mediated photoredox hydroarylation with thiosulfonate
Xiaoyuan Wan, Dahan Wang, Huawen Huang, Guojiang Mao, Guo‐Jun Deng
Abstract
Herein, we report a novel visible light-induced photocatalytic system that enables intramolecular hydroarylation of unactivated alkenes. Thiosulfonate compounds were found to be the key radical precursor that mediates the Minisci-type intramolecular cyclization reaction. Under the optimal reaction conditions, a wide range of pyridyquinazolinone and pyrroloquinazolinone products were obtained in moderate to good yields.
Topics & Concepts
ChemistryCombinatorial chemistryPhotoredox catalysisOrganic chemistryPhotocatalysisCatalysisRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods