First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases
Moustafa T. Gabr, Florent Barbault
Abstract
We report a new approach for the development of multitargeted therapeutics for Alzheimer's disease (AD) based on dual targeting of monomeric tau and biogenesis of microRNA-146a. Compound MG-1102 displayed a superior neuroprotective activity, in comparison to mono-targeted therapeutics, which validates the likelihood of the success of this approach in AD drug development.
Topics & Concepts
MonomerDual (grammatical number)microRNAChemistryCancer researchNeuroscienceCombinatorial chemistryMedicineBiochemistryBiologyOrganic chemistryGenePolymerPhilosophyLinguisticsMicroRNA in disease regulationRNA Interference and Gene DeliveryCircular RNAs in diseases