Association between Vitamin D Deficiency and Levels of Renin and Angiotensin in Essential Hypertension
Lu Han, XU Xin-juan, Junshi Zhang, Haiming Liu
Abstract
Objective . The present study aims to investigate the relationship between vitamin D deficiency and renin‐angiotensin‐aldosterone levels in patients with essential hypertension. Methods . The present study observed two groups of patients from Urumqi, Xinjiang, China, from April 2017 to March 2018. There were two subject groups: the hypertension group (80 patients with essential hypertension selected by random cluster sampling) and the control group (76 healthy adults). The 25‐hydroxyvitamin D (25(OH)D or vitamin D) levels were measured through electrolytes; fasting blood glucose, blood lipids, and other biochemical indicators were detected using immune chemiluminescence; and plasma renin activity and angiotensin II concentrations were detected with radio‐immunity. Results . Comparison between the hypertension group and control group showed statistically significant differences in the systolic pressure and levels of 25(OH)D, renin, and triglycerides ( P < 0.05). The correlation analysis showed that 25(OH)D was negatively correlated with renin ( r = –0.185; P = 0.021) and positively correlated with systolic pressure ( r = –0.105; P = 0.035). There were no statistically significant differences in diastolic pressure, fasting blood glucose, total cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and triglycerides between the two groups. Conclusions . The results of the present study show that vitamin D deficiency is common in Urumqi, Xinjiang, China and vitamin D levels are negatively correlated with renin levels. Vitamin D plays an important role in regulating blood pressure by affecting renin levels through the renin‐angiotensin‐aldosterone system.