Electrochemical-Promoted Nickel-Catalyzed Oxidative Fluoroalkylation of Aryl Iodides
Zhenlei Zou, Heyin Li, Mengjun Huang, Weigang Zhang, Sanjun Zhi, Yi Wang, Yi Pan
Abstract
This work describes a general strategy for metal-catalyzed cross-coupling of fluoroalkyl radicals with aryl halides under electrochemical conditions. The contradiction between anodic oxidation of fluoroalkyl sulfinates and cathodic reduction of low-valent nickel catalysts can be well addressed by paired electrolysis, allowing for direct introduction of fluorinated functionalities into aromatic systems.
Topics & Concepts
ChemistryHalideCatalysisArylElectrolysisElectrochemistryNickelCathodic protectionCombinatorial chemistryRadicalAnodeOxidative coupling of methaneMetalInorganic chemistryOrganic chemistryElectrolyteAlkylElectrodePhysical chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques