Cp*Co(III)-Catalyzed C-7 C–C Coupling of Indolines with Aziridines: Merging C–H Activation and Ring Opening
Pinaki Bhusan De, Sayan Atta, Sourav Pradhan, Sonbidya Banerjee, Tariq A. Shah, Tharmalingam Punniyamurthy
Abstract
A Cp*Co(III)-catalyzed directing group-assisted C7 C-C coupling of indolines with aziridines has been developed by merging C-H activation and ring opening. The use of cobalt catalyst, detection of a Co(III) intermediate, and late-stage removal of the directing group are important practical features.
Topics & Concepts
ChemistryCatalysisRing (chemistry)CobaltCoupling (piping)Group (periodic table)Medicinal chemistryStereochemistryOrganic chemistryMechanical engineeringEngineeringCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis