A paradigm shift in structural biology
Sriram Subramaniam, Gerard J. Kleywegt
Abstract
The release of protein structure predictions from AlphaFold will increase the number of protein structural models by almost three orders of magnitude. Structural biology and bioinformatics will never be the same, and the need for incisive experimental approaches will be greater than ever. Combining these advances in structure prediction with recent advances in cryo-electron microscopy suggests a new paradigm for structural biology.
Topics & Concepts
Structural biologyComputational biologyParadigm shiftBiologyCryo-electron microscopyComputer scienceBiophysicsPhysicsCell biologyQuantum mechanicsAdvanced Electron Microscopy Techniques and ApplicationsEnzyme Structure and FunctionProtein Structure and Dynamics