M2 microglial small extracellular vesicles reduce glial scar formation <i>via</i> the miR-124/STAT3 pathway after ischemic stroke in mice
Zongwei Li, Yaying Song, Tingting He, Ruoxue Wen, Yong-Fang Li, Tingting Chen, Shuxian Huang, Yongting Wang, Yaohui Tang, Fanxia Shen, Heng‐Li Tian, Guo‐Yuan Yang, Zhijun Zhang
Abstract
small extracellular vesicles, indicating that M2 microglial small extracellular vesicles could represent a new therapeutic approach for stroke.
Topics & Concepts
Extracellular vesiclesMicrogliaGlial scarStroke (engine)Cell biologyExtracellularChemistrySTAT3Ischemic strokeInflammationCancer researchPathologyMedicineNeuroscienceAstrocyteCentral nervous systemBiologyIschemiaSignal transductionImmunologyInternal medicineMechanical engineeringEngineeringExtracellular vesicles in diseaseNeuroinflammation and Neurodegeneration MechanismsMicroRNA in disease regulation