S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression
Weijing He, Jingjing Zhang, Baihui Liu, Xiangqi Liu, Gongbao Liu, Lulu Xie, Jiajun He, Meng Wei, Kai Li, Jing Ma, Rui Dong, Duan Ma, Kuiran Dong, Mujie Ye
Abstract
. Furthermore, experimental results also suggested that solute carrier family 7 member 1 (SLC7A1) might be a substrate of SPOP and influence cell phenotype by regulating arginine metabolism. In conclusion, these findings demonstrated the function of SPOP and revealed a potential substrate related to hepatoblastoma tumorigenesis, which might thus provide a novel therapeutic target for hepatoblastoma.
Topics & Concepts
Ubiquitin ligaseHepatoblastomaUbiquitinCancer researchDegradation (telecommunications)MutationUbiquitin-Protein LigasesChemistryCell biologyGeneticsBiologyMedicineInternal medicineComputer scienceGeneTelecommunicationsUbiquitin and proteasome pathwaysCancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation