Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis
Kai Qu, Yan Fang, Xian Qin, Kun Zhang, Wen He, Mingqing Dong, Guicheng Wu
Abstract
the electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species accumulation, energy stress, and cell death. Endothelial mitochondrial dysfunction is an important factor causing abnormal function of the endothelium, which plays a central role during atherosclerosis development. Atherosclerosis-related risk factors, including high glucose levels, hypertension, ischemia, hypoxia, and diabetes, promote mitochondrial dysfunction in endothelial cells. This review summarizes the physiological and pathophysiological roles of endothelial mitochondria in endothelial function and atherosclerosis.
Topics & Concepts
Endothelial dysfunctionMitochondrionEndotheliumHypoxia (environmental)OrganelleEndothelial stem cellIschemiaReactive oxygen speciesCell biologyPathophysiologyVascular endothelial growth factor BBiologyMedicineInternal medicineEndocrinologyChemistryVascular endothelial growth factor AVascular endothelial growth factorBiochemistryOxygenVEGF receptorsIn vitroOrganic chemistryMitochondrial Function and PathologyNitric Oxide and Endothelin EffectsATP Synthase and ATPases Research