Early onset pancreatic cancer: A review
Dong Luo, Yixiong Li, Xiao Yu, Liandong Ji, Xuejun Gong
Abstract
• EOPC is a rare subgroup with distinctive clinical and molecular characteristics. • Studies at the molecular level are far from sufficient. • EOPC patients mainly presented no difference in survival outcomes and better survival outcomes than AOPC/LOPC. Early-onset pancreatic cancer (EOPC) is usually defined as patients with pancreatic cancer before the age of 50 years, which is relatively rare. However, the research on EOPC is somewhat obscure, and the specific clinical and molecular characteristics of this condition are debated. In this review, we discussed the differences between EOPC and late-onset pancreatic cancer (LOPC) or average-onset pancreatic cancer (AOPC) with a focus on clinical and molecular characteristics, survival outcomes and treatment to promote the diagnosis and treatment of EOPC.