Discovery of novel triazoles containing benzyloxy phenyl isoxazole side chain with potent and broad-spectrum antifungal activity
Xiaochen Chi, Fei Xie, Liping Li, Yumeng Hao, Hao Wu, Xianru Li, Guangxin Xia, Lan Yan, Dazhi Zhang, Yuanying Jiang, Tingjunhong Ni
Topics & Concepts
PotencyChemistryIsoxazoleIn vitroIn vivoCandida albicansPharmacophoreCYP3A4StereochemistrySide chainMinimum inhibitory concentrationCryptococcus neoformansBiological activityPharmacologyBiochemistryMicrobiologyEnzymeBiologyCytochrome P450Organic chemistryBiotechnologyPolymerAntifungal resistance and susceptibilitySynthesis and Biological EvaluationFungal Infections and Studies