Synthesis of Antibacterial Gelatin/Sodium Alginate Sponges and Their Antibacterial Activity
Yanyi Wen, Bing Yu, Zhongjie Zhu, Zhuoran Yang, Wei Shao
Abstract
In the present study, sponges with the antibiotic tetracycline hydrochloride (TCH) loaded into alginate incorporated with gelatin (G/SA) were fabricated. The G/SA sponges were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric (TG) analysis. G/SA sponges show a three-dimensional network structure with high porosity. An excellent swelling behavior and a controlled TCH release performance are observed from G/SA sponges. Moreover, they exhibit good antibacterial activity against both Gram-positive and Gram-negative bacteria.
Topics & Concepts
Thermogravimetric analysisGelatinAntibacterial activityFourier transform infrared spectroscopyTetracycline HydrochlorideNuclear chemistrySwellingScanning electron microscopeSpongeChemistryMaterials scienceTetracyclineBacteriaChemical engineeringOrganic chemistryAntibioticsBiochemistryComposite materialBotanyBiologyEngineeringGeneticsGraphene and Nanomaterials ApplicationsHydrogels: synthesis, properties, applicationsAdvanced Drug Delivery Systems