Discovery of an Antarctic Ascidian-Associated Uncultivated <i>Verrucomicrobia</i> with Antimelanoma Palmerolide Biosynthetic Potential
Alison E. Murray, Chien‐Chi Lo, Hajnalka Daligault, Nicole E. Avalon, Robert W. Read, Karen W. Davenport, Mary L. Higham, Yuliya A. Kunde, Armand E. K. Dichosa, Bill J. Baker, Patrick Chain
Abstract
. Synoicihabitans palmerolidicus 4.29-Mb genome encodes a repertoire of carbohydrate-utilizing and transport pathways, a chemotaxis system, flagellar biosynthetic capacity, and other regulatory elements enabling its ascidian-associated lifestyle. The palmerolide producer's genome also contains five distinct copies of the large palmerolide biosynthetic gene cluster that may provide structural complexity of palmerolide variants.
Topics & Concepts
VerrucomicrobiaBiologyZoologyAstrobiologyBiochemistryGene16S ribosomal RNAActinobacteriaMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsSynthesis and Catalytic Reactions