Synthesis of a heparan sulfate tetrasaccharide using automated glycan assembly
Imlirenla Pongener, Eric T. Sletten, José Danglad‐Flores, Peter H. Seeberger, Gavin J. Miller
Abstract
Herein we utilise automated glycan assembly to complete solid-phase synthesis of defined heparan sulfate oligosaccharides, employing on resin O-sulfation and d -glucuronate disaccharide donors.
Topics & Concepts
GlycanTetrasaccharideHeparan sulfateSulfationGlucuronateChemistryDisaccharideSulfateBiochemistryStereochemistryCombinatorial chemistryGlycosaminoglycanOrganic chemistryPolysaccharideGlycoproteinProteoglycans and glycosaminoglycans researchCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins Research