PDLIM1: Structure, function and implication in cancer
Jiankang Zhou, Xin Fan, Jian Cheng, Wenrong Liu, Yong Peng
Abstract
PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. Emerging evidence demonstrates that PDLIM1 is dysregualted in a variety of tumors and plays essential roles in tumor initiation and progression. In this review, we summarize the structure and function of PDLIM1, as well as its important roles in human cancers.
Topics & Concepts
PDZ domainCytoskeletonFunction (biology)CancerBiologyCell biologyComputational biologyNeuroscienceGeneticsCellHippo pathway signaling and YAP/TAZCell death mechanisms and regulationCell Adhesion Molecules Research