An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury
Xiang Gao, Zhihui Han, Cheng Huang, Huali Lei, Guangqiang Li, Lin Chen, Feng Dandan, Zijie Zhou, Qin Shi, Liang Cheng, Xiaozhong Zhou
Abstract
experiments revealed that RA@BSA@Cur NPs regulated the phenotypic polarization of macrophages, inhibited the release of inflammatory mediators, promoted functional neuron regeneration and motor function, and further inhibited scar tissue formation. This study highlighted that the BSA-based biomimetic nanomaterials could be used as ROS scavengers and nerve regeneration promoters for treating SCI.
Topics & Concepts
NeuriteNeuroprotectionSpinal cord injuryChemistryCell biologyMesenchymal stem cellCurcuminRegeneration (biology)AstrocyteNeural stem cellMicrogliaPharmacologySpinal cordStem cellInflammationImmunologyIn vitroBiochemistryCentral nervous systemBiologyNeuroscienceSpinal Cord Injury ResearchNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms