MGAT3-mediated glycosylation of tetraspanin CD82 at asparagine 157 suppresses ovarian cancer metastasis by inhibiting the integrin signaling pathway
Jun Li, Jiawen Xu, Luhan Li, Alessandro Ianni, Poonam Kumari, Shuo Liu, Peiqing Sun, Thomas Braun, Xiaoyue Tan, Rong Xiang, Shijing Yue
Abstract
: Our work implicates a pathway for ovarian cancers metastasis regulation via MGAT3 mediated glycosylation of tetraspanin CD82 at asparagine 157.
Topics & Concepts
TetraspaninCancer researchMetastasisOvarian cancerIntegrinGlycosylationCell biologyChemistrySignal transductionCancerBiologyMedicineBiochemistryInternal medicineCellGlycosylation and Glycoproteins ResearchCell Adhesion Molecules ResearchProteoglycans and glycosaminoglycans research