Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition
Rosario Notaro, Lucio Luzzatto
Abstract
Inhibitors of proximal and terminal complement cascades can often control red-cell hemolysis associated with paroxysmal nocturnal hemoglobinuria, but some patients have breakthrough hemolysis.
Topics & Concepts
Paroxysmal nocturnal hemoglobinuriaHemolysisComplement (music)CD59Complement systemTerminal (telecommunication)Red blood cellHemoglobinuriaImmunologyMedicineChemistryBiochemistryComputer scienceAntibodyTelecommunicationsPhenotypeGeneComplementationComplement system in diseasesBlood groups and transfusionAdenosine and Purinergic Signaling