Novel Insights into the Classification of Staphylococcal β-Lactamases in Relation to the Cefazolin Inoculum Effect
Lina P Carvajal, Sandra Rincón, Aura M Echeverri, Jessica Porras, Rafael Ríos, Karen Ordóñez, Carlos Seas, Sara I Gómez-Villegas, Lorena Díaz, César A. Arias, Jinnethe Reyes
Abstract
Cefazolin has become a prominent therapy for methicillin-susceptible Staphylococcus aureus (MSSA) infections. However, an important concern is the cefazolin inoculum effect (CzIE), a phenomenon mediated by staphylococcal β-lactamases. Four variants of staphylococcal β-lactamases have been described based on serological methodologies and limited sequence information. Here, we sought to reassess the classification of staphylococcal β-lactamases and their correlation with the CzIE.
Topics & Concepts
CefazolinStaphylococcus aureusMicrobiologyStaphylococcal infectionsBiologyStaphylococcusAntibioticsBacteriaGeneticsAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility Testing