Effect of Oriented Electric Fields on Biologically Relevant Iron–Sulfur Clusters: Tuning Redox Reactivity for Catalysis
Samuel J. H. Gaughan, Jonathan D. Hirst, Anna K. Croft, Christof M. Jäger
Abstract
. This shows clear implications for the reactivity of iron-sulfur clusters in enzymes. The results also demonstrate that the orientation of the electric field can alter the most stable broken-symmetry state, which further has implications on the directionality of initiated electron-transfer reactions. These insights open the path for manipulating the enzymatic redox reactivity of iron-sulfur cluster-containing enzymes by rationally engineering oriented electric fields within the enzymes.
Topics & Concepts
Reactivity (psychology)RedoxChemistryElectron transferCluster (spacecraft)Iron–sulfur clusterActive siteElectric fieldEnzyme catalysisSulfurEnzymeElectron transport chainChemical physicsCombinatorial chemistryComputational chemistryPhotochemistryInorganic chemistryOrganic chemistryPhysicsBiochemistryAlternative medicineQuantum mechanicsComputer scienceProgramming languageMedicinePathologyMetalloenzymes and iron-sulfur proteinsElectrocatalysts for Energy ConversionAdvanced battery technologies research