Copper-catalyzed asymmetric silyl addition to alkenyl-substituted <i>N</i>-heteroarenes
Yali Zeng, Bo Chen, Yating Wang, Cheng‐Yu He, Zi-Yuan Mu, Jiyuan Du, Long He, Wen‐Dao Chu, Quan‐Zhong Liu
Abstract
Asymmetric conjugate addition of PhMe2SiBPin to a wide range of N-heteroaryl alkenes proceeded in the presence of a copper catalyst coordinated with an easily accessible chiral phosphoramidite ligand to afford useful β-silyl N-heteroarenes in high yields (up to 96%) and excellent enantioselectivities (up to 97% ee).
Topics & Concepts
SilylationPhosphoramiditeCatalysisConjugateChemistryCopperMedicinal chemistryLigand (biochemistry)Organic chemistryMathematicsReceptorDNAOligonucleotideBiochemistryMathematical analysisAsymmetric Synthesis and CatalysisOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and Catalysis