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Atg1-mediated Atg11 phosphorylation is required for selective autophagy by regulating its association with receptor proteins

Weijing Yao, Yixing Li, Yingcong Chen, Yuting Chen, Yu Xie, Miaojuan Ye, Ying Zhang, Xiangjun Chen, Xiaoyong Wu, Yuyao Feng, Zhi Hong, Yigang Wang, Wei Liu, Cong Yi

2022Autophagy18 citationsDOIOpen Access PDF

Abstract

: AMPK: AMP-activated protein kinase; ATG: autophagy-related; Cvt: cytoplasm-to-vacuole targeting; FUNDC1: FUN14 domain-containing protein 1; GFP: green fluorescent protein; MTOR: mechanistic target of rapamycin kinase; PAS: phagophore assembly site; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PRKAC/PKA: protein kinase cAMP-activated; SD-G: glucose starvation; SD-N: nitrogen starvation; ULK1: unc-51 like autophagy activating kinase 1; λ-PPase: lambda protein phosphatase.

Topics & Concepts

AutophagyBiologyMitophagyCell biologyPhosphorylationBAG3Autophagy-related protein 13BiochemistrySignal transducing adaptor proteinVacuoleProtein kinase ACytoplasmProtein phosphorylationApoptosisAutophagy in Disease and TherapyCellular transport and secretionCalcium signaling and nucleotide metabolism
Atg1-mediated Atg11 phosphorylation is required for selective autophagy by regulating its association with receptor proteins | Litcius