(p)ppGpp/GTP and Malonyl-CoA Modulate Staphylococcus aureus Adaptation to FASII Antibiotics and Provide a Basis for Synergistic Bi-Therapy
Amit Pathania, Jamila Anba‐Mondoloni, Myriam Gominet, David Halpern, Julien Dairou, Laëtitia Dupont, Gilles Lamberet, Patrick Trieu‐Cuot, Karine Gloux, Alexandra Gruss
Abstract
Staphylococcus aureus is a major human bacterial pathogen for which new inhibitors are urgently needed. Antibiotic development has centered on the fatty acid synthesis (FASII) pathway, which provides the building blocks for bacterial membrane phospholipids.
Topics & Concepts
Staphylococcus aureusGTP'AntibioticsChemistryMicrobiologyAdaptation (eye)BacteriaBiologyBiochemistryNeuroscienceEnzymeGeneticsProbiotics and Fermented FoodsMicrobial Metabolism and ApplicationsAntimicrobial Resistance in Staphylococcus