Regulation of Ribosomal Protein Synthesis in Prokaryotes
Alisa Mikhaylina, Ekaterina Nikonova, Olga Kostareva, Svetlana Tishchenko
Abstract
Protein synthesis on ribosomes is considered the main process in cell life. Regulation of ribosomal protein gene expression plays an important role in the balanced synthesis of proteins and RNA in ribosomal biogenesis. This review is focused on some features of autoregulation of ribosomal protein synthesis in prokaryotes. Inhibition of the synthesis of ribosomal proteins encoded by 12 operons by mechanisms of competition , “entrapment”, and retroregulation are discussed. Examples of regulation of protein synthesis by individual ribosomal proteins and their complexes are presented.
Topics & Concepts
Ribosomal proteinRibosomeRibosomal RNARibosome biogenesis5S ribosomal RNAProtein biosynthesisOperon28S ribosomal RNAEukaryotic Large Ribosomal SubunitBiologyGeneRNACell biologyBiochemistryEscherichia coliRNA and protein synthesis mechanismsRNA modifications and cancerEnzyme Structure and Function