Construction of CF<sub>3</sub>-Containing Tetrahydropyrano[3,2-<i>b</i>]indoles through DMAP-Catalyzed [4+1]/[3+3] Domino Sequential Annulation
Yannan Zhu, You Huang
Abstract
]indoles were obtained as a single diastereomer in high yields (≤98%) under mild conditions. The reaction can build one C-N bond, one C-C bond, and one C-O bond sequentially in a single step. The synthetic utility was demonstrated with gram-scale reactions and various transformations of the products.
Topics & Concepts
AnnulationChemistryDominoDiastereomerCatalysisCombinatorial chemistryReaction conditionsStereochemistryMedicinal chemistryOrganic chemistryFluorine in Organic ChemistryCarbohydrate Chemistry and SynthesisAsymmetric Synthesis and Catalysis