Acute myeloid leukemia shapes the bone marrow stromal niche <i>in vivo</i>
Alice Pievani, Samantha Donsante, Chiara Tomasoni, Alessandro Corsi, Francesco Dazzi, Andrea Biondi, Mara Riminucci, Marta Serafini
Abstract
Emerging evidence suggests that acute myeloid leukemia (AML) remodels the bone marrow (BM) niche into a leukemia-permissive microenvironment, while suppressing normal hematopoiesis.
Topics & Concepts
Bone marrowIn vivoMyeloid leukemiaStromal cellCancer researchMyeloidLeukemiaNicheMedicineBiologyImmunologyGeneticsBiochemistryHematological disorders and diagnosticsHematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research