2-Guanidyl pyridine PNA nucleobase for triple-helical Hoogsteen recognition of cytosine in double-stranded RNA
C.A. Ryan, Vladislavs Baskevics, Mārtiņš Katkevičs, Eriks Rozners
Abstract
and molecular dynamics simulations provided insights into H-bonding interactions that stabilized V·C-G triplets. Our results provided insights for future design of improved nucleobases, which is an important step towards the ultimate goal of recognition of any sequence of dsRNA.
Topics & Concepts
NucleobaseCytosinePeptide nucleic acidChemistryNucleic acidPyridineAb initioTriple helixBase pairStereochemistryMolecular recognitionGuanineCrystallographyDNANucleotideMoleculeBiochemistryOrganic chemistryGeneRNA Interference and Gene DeliveryDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms