An ALP enzyme-based electrochemical biosensor coated with signal-amplifying BaTiO<sub>3</sub> nanoparticles for the detection of an antiviral drug in human blood serum
Muhammad Umar Draz, Muhammad Zia Ul Haq, Akhtar Hayat, Huma Ajab
Abstract
nanoparticles, and drug incubation time were optimized. The biosensor demonstrated an outstanding limit of detection (LOD) of 0.09 nM and recovery percentages of 98.6-106% in human blood serum, indicating adequate repeatability and selectivity. The proposed biosensor can be converted into a portable device for measuring small sample volumes and observing patients for immediate medical care or personalized therapies. It achieved better sensitivity compared to existing methods, making it suitable for precise drug detection in microdoses.
Topics & Concepts
BiosensorHuman bloodDrugNanoparticleDrug detectionEnzymeElectrochemistrySIGNAL (programming language)NanotechnologyMaterials scienceChemistryChromatographyPharmacologyBiochemistryElectrodeMedicineComputer sciencePhysiologyPhysical chemistryProgramming languageAdvanced biosensing and bioanalysis techniquesElectrochemical sensors and biosensorsBiosensors and Analytical Detection