Widespread Detection of Yersiniabactin Gene Cluster and Its Encoding Integrative Conjugative Elements (ICE <i>Kp</i> ) among Nonoutbreak OXA-48-Producing <i>Klebsiella pneumoniae</i> Clinical Isolates from Spain and the Netherlands
AFIF PRANAYA JATI, Pedro J. Sola‐Campoy, Thijs Bosch, Leo M. Schouls, Antoni P. A. Hendrickx, Verónica Bautista, Noelia Lara, Erwin C. Raangs, Belén Aracil, John W. A. Rossen, Alex W. Friedrich, A. Riaza, J. Cañada, Eva Ramírez de Arellano, Jesús Oteo, Marı́a Pérez-Vázquez, Silvia García-Cobos, The Dutch and Spanish Collaborative Working Groups on Surveillance on Carbapenemase-Producing Enterobacterales, A. Maijer-Reuwer, Michael Hall, Wouter van den Bijllaardt, Rosa van Mansfeld, Karin van Dijk, B. Zwart, B. M. W. Diederen, J W Dorigo-Zetsma, Daan W. Notermans, Alewijn Ott, W. Ang, J Silvia, A. L. M. Vlek, A. G. M. Buiting, L. Bode, S. Paltansing, A. J. van Griethuysen, M den Reijer, M. J. C. A. van Trijp, Marcus Ho Yin Wong, Anouk E. Muller, M. P. M. van der Linden, M. van Rijn, S. B. Debast, K. Waar, Eva Kolwijck, N. Alnaiemi, T. Schülin, S. Dinant, S. P. van Mens, Damian C. Melles∗, J. W. T. Cohen Stuart, M L van Ogtrop, I. T. M. A. Overdevest, Alje P. van Dam, Ianthe Maat, B. Maraha, J. C. Sinnige, Eva Mattsson, M. van Meer, A. Stam, E.M.G.J. de Jong, Saara Vainio, E. Heikens, Radjin Steingrover, Annet Troelstra, Erik Bathoorn, T. A. M. Trienekens, D. W. van Dam, E. I. G. B. de Brauwer, Germán Bou, Juan Manuel Herrera Hernández, Ana María Sánchez, Ana Fleites, Carlos Rodríguez-Lucas, María Victoria García-López, María Ángeles Orellana, Carmina Martí-Sala, M. Pulido, Mayuli Armas, Emilia Cercenado, Alejandro González‐Praetorius, Sonia Solís, María Isabel Sánchez-Romero, Rafael Cantón, Patricia Ruíz-Garbajosa, Luis López-Urrutia Lorente, Pedro de la Iglesia, Beatriz Menéndez Iglesias, Guillermo Ruíz-Carrascoso, Mar Olga Pérez Moreno, Rosa Bartolomé, Juan José González‐López, Carmen Conejo, Álvaro Pascual, José Antonio Rodríguez-Polo
Abstract
Convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae isolates has been reported mostly related to sporadic cases or small outbreaks. Nevertheless, little is known about the real prevalence of carbapenem-resistant hypervirulent K. pneumoniae since these two phenomena are often separately studied. In this study, we gathered information on the virulent content of nonoutbreak, high-risk clones (i.e., ST11, ST15, and ST405) and other less common STs associated with the spread of OXA-48-producing K. pneumoniae clinical isolates. The study of virulence content in nonoutbreak isolates can help us to expand information on the genomic landscape of virulence factors in K. pneumoniae population by identifying virulence markers and their mechanisms of spread. Surveillance should focus not only on antimicrobial resistance but also on virulence characteristics to avoid the spread of multidrug and (hyper)virulent K. pneumoniae that may cause untreatable and more severe infections.