Rutin attenuates <scp>d</scp>-galactose-induced oxidative stress in rats’ brain and liver: molecular docking and experimental approaches
Shaimaa M. Saafan, Shymaa A. Mohamed, Ahmed E. Noreldin, Fayza A. El Tedawy, Yaser Hosny Ali Elewa, Reda Fadly, Soad K. Al Jaouni, Ali H. El‐Far, Abdelwahab A. Alsenosy
Abstract
-galactosidase, 8-hydroxy-2'-deoxyguanosine, calcium-binding adapter molecule 1, glial fibrillary acidic protein, Bax, and interleukin-6 and significantly increased Bcl2, synaptophysin, and Ki67. Furthermore, a molecular docking study revealed that rutin exhibited high affinity to rat and human caspases, PI3K/AKT/mTOR, and the IL-6 receptor. Finally, we can conclude that rutin supplementation can be a promising natural protective compound that could delay aging and maintain health.
Topics & Concepts
Oxidative stressRutinReactive oxygen speciesChemistryGlutathione peroxidaseGlutathionePharmacologySuperoxide dismutaseBiochemistryAntioxidantBiologyEnzymeAntioxidants, Aging, Portulaca oleraceaBiochemical effects in animalsBiochemical Acid Research Studies