DCAF7 regulates cell proliferation through IRS1-FOXO1 signaling
Scott Frendo‐Cumbo, Taoyingnan Li, Dustin A. Ammendolia, Étienne Coyaud, Estelle Laurent, Yuan Liu, Philip J. Bilan, Gordon Polevoy, Brian Raught, Julie A. Brill, Amira Klip, John H. Brumell
Abstract
. We propose that DCAF7 regulates cell proliferation and cell cycle via IRS1-FOXO1 signaling, of relevance to whole organism growth.
Topics & Concepts
Gene knockdownCell growthFOXO1Cell cycleCell biologyBiologyTranscription factorProtein kinase BSignal transductionPI3K/AKT/mTOR pathwayCellGeneticsCell cultureGeneFOXO transcription factor regulationUbiquitin and proteasome pathwaysProtein Degradation and Inhibitors