Silencing IQGAP1 alleviates hepatic fibrogenesis via blocking bone marrow mesenchymal stromal cell recruitment to fibrotic liver
Yuehan Ma, Na Chang, Yuran Liu, Fuquan Liu, Chengbin Dong, Lei Hou, Changbo Qi, Lin Yang, Liying Li
Abstract
, silencing IQGAP1 reduces the recruitment of BMSCs to impaired liver and effectively alleviates liver fibrosis induced by MCDHF diet. Together, silencing IQGAP1 relieves liver fibrosis by blocking BMSC migration, providing an effective therapeutic strategy for liver fibrosis.
Topics & Concepts
IQGAP1Cell biologyGene silencingFibrosisRAC1Cancer researchStromal cellSmall interfering RNABiologyMesenchymal stem cellChemistryPathologySignal transductionCell cultureMedicineTransfectionScaffold proteinGeneGeneticsBiochemistryLiver physiology and pathologySphingolipid Metabolism and SignalingPI3K/AKT/mTOR signaling in cancer