Synthesis and antimicrobial evaluation of new 2‐pyridinone and 2‐iminochromene derivatives containing morpholine moiety
Mohamed A. Salem, Samir Y. Abbas, Mohamed H. Helal, Abdullah Yahya Abdullah Alzahrani
Abstract
Abstract As trail to overcome on the antimicrobial drug‐resistance problems, new functionalized 2‐pyridinone and 2‐iminochromene derivatives bearing morpholine moiety were designed and synthesized. The 2‐pyridinone derivatives were obtained through the cyclization of cyanoacetohydrazone of 4‐morpholinylacetophenone with 1,3‐dicarbonyl compounds, α , β ‐unsaturated nitriles or 2‐(arylidene)malononitriles. The 2‐iminochromene derivatives were synthesized through the ring closure of cyanoacetohydrazonewith salicylaldehyde derivatives. The antibacterial and antifungal activities for the synthesized 2‐pyridinone and 2‐iminochromene derivatives were investigated. Most of the tested compounds showed moderate activity against P . vulgaris . Compounds 4a,b and 5a,b showed moderate activity against G −ve bacteria. All iminochromene derivatives showed moderate activity against C . albicans . Compound 8c was the most active compound.