Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1
Thordur Hendrickson-Rebizant, S Sudhakar, Michael J. Rowley, Adam Frankel, James Davie, Ted M. Lakowski
Abstract
-methylethylenediamine inhibitors of PRMT1 and review current progress of PRMT1 inhibitors in clinical trials.
Topics & Concepts
ChemistryArgininePeptideProtein arginine methyltransferase 5MethyltransferaseFunction (biology)Small moleculeBiochemistryStructure–activity relationshipAmino acidIn vitroCell biologyMethylationGeneBiologyCancer-related gene regulationEpigenetics and DNA Methylation