Heteroarylation of unactivated C–H bonds suitable for late-stage functionalization
Austin S. Miller, Erik J. Alexanian
Abstract
-alkenylhydroxamate with heterocyclic sulfone partners. The C-H heteroarylation proceeds efficiently with a range of aliphatic substrates and common heterocycles, and is a rare example of heteroarylation of strong C-H bonds. Importantly, the present approach is amenable to late-stage functionalization as the substrate is the limiting reagent in all cases.
Topics & Concepts
Surface modificationStage (stratigraphy)Combinatorial chemistryChemistryStereochemistryBiologyPaleontologyPhysical chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions