A simple and rapid LC-MS/MS method for the simultaneous determination of eight antipsychotics in human serum, and its application to therapeutic drug monitoring
Yun‐Feng Cao, Furong Zhao, Jianxing Chen, Ting Huang, Jia Zeng, Lu Wang, Xiaoyu Sun, Yanming Miao, Shuang Wang, Chunwu Chen
Topics & Concepts
ChemistryChromatographyProtein precipitationAmmonium formateTherapeutic drug monitoringAnalyteSelected reaction monitoringAripiprazoleChlorzoxazoneExtraction (chemistry)ElutionTandem mass spectrometryMass spectrometryPharmacokineticsPharmacologyMetabolismBiochemistryProgramming languageCytochrome P450Schizophrenia (object-oriented programming)MedicineComputer scienceCYP2E1Metabolomics and Mass Spectrometry StudiesAnalytical Chemistry and ChromatographySchizophrenia research and treatment