Dichloroacetophenone biphenylsulfone ethers as anticancer pyruvate dehydrogenase kinase inhibitors in non-small cell lung cancer models
Yizhen Guo, Yan Zhou, Puhua Wu, Maoxin Ran, Ngai Xu, Wenying Shan, Ou Sha, Kin Yip Tam
Topics & Concepts
Cancer researchApoptosisLactate dehydrogenaseKinaseChemistryPyruvate kinaseCell growthPyruvate dehydrogenase kinasePharmacologyEnzymeCancerCancer cellExtracellularCell cultureBiochemistryPyruvate dehydrogenase complexBiologyGlycolysisMedicineInternal medicineGeneticsCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchEpigenetics and DNA Methylation