TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis
Hongrui Guo, Zhijie Jian, Huan Liu, Hengmin Cui, Huidan Deng, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Topics & Concepts
SMADPulmonary fibrosisSignal transductionTransforming growth factorMAPK/ERK pathwayEpithelial–mesenchymal transitionChemistryFibrosisSmad2 ProteinVimentinCancer researchCell biologyBiologyInternal medicineDownregulation and upregulationMedicineBiochemistryImmunohistochemistryGeneInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational and environmental lung diseasesOccupational exposure and asthma