Discovery of potent and highly selective covalent inhibitors of Bruton’s tyrosine kinase bearing triazine scaffold
Yu Teng, Xiang Lü, Maoxu Xiao, Zhenbang Li, Yumei Zou, Shengnan Ren, Yu Cheng, Guoshun Luo, Hua Xiang
Topics & Concepts
Bruton's tyrosine kinaseADMEChemistryTyrosine kinaseIbrutinibRaji cellBiochemistryKinasePharmacologySignal transductionCellLeukemiaIn vitroBiologyImmunologyChronic lymphocytic leukemiaChronic Lymphocytic Leukemia ResearchCAR-T cell therapy researchChronic Myeloid Leukemia Treatments