β-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates
Montserrat Mora-Ochomogo, Christopher T. Lohans
Abstract
Overview of β-lactam antibiotics and the proteins with which they covalently interact, focusing on penicillin-binding proteins and serine β-lactamases.
Topics & Concepts
AntibioticsCovalent bondAntibiotic resistanceChemistryMicrobiologyBiologyBiochemistryOrganic chemistryAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPneumocystis jirovecii pneumonia detection and treatment