Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis
Sara Di Persio, Tobias Tekath, Lara Marie Siebert-Kuss, Jann‐Frederik Cremers, Joachim Wistuba, Xiaolin Li, Gerd Meyer zu Hörste, Hannes C. A. Drexler, Margot J. Wyrwoll, Frank Tüttelmann, Martin Dugas, Sabine Kliesch, Stefan Schlatt, Sandra Laurentino, Nina Neuhaus
Abstract
spermatogonia, characterized by tightly compacted chromatin and serving as reserve stem cells. These findings suggest that crypto patients are disadvantaged, as fewer cells safeguard their germline's genetic integrity. These identified spermatogonial regulators will be highly interesting targets to uncover genetic causes of male infertility.
Topics & Concepts
Compartment (ship)SpermatogenesisStem cellCell biologyCellRNABiologyGeneticsGeneEndocrinologyOceanographyGeologyReproductive Biology and FertilityRenal and related cancersSperm and Testicular Function