Similar Disease Prediction With Heterogeneous Disease Information Networks
Jianliang Gao, Ling Tian, Jianxin Wang, Yibo Chen, Bo Song, Xiaohua Hu
Abstract
Studying the similarity of diseases can help us to explore the pathological characteristics of complex diseases, and help provide reliable reference information for inferring the relationship between new diseases and known diseases, so as to develop effective treatment plans. To obtain the similarity of the disease, most previous methods either use a single similarity metric such as semantic score, functional score from single data source, or utilize weighting coefficients to simply combine multiple metrics with different dimensions. In this paper, we proposes a method to predict the similarity of diseases by node representation learning. We first integrate the semantic score and topological score between diseases by combining multiple data sources. Then for each disease, its integrated scores with all other diseases are utilized to map it into a vector of the same spatial dimension, and the vectors are used to measure and comprehensively analyze the similarity between diseases. Lastly, we conduct comparative experiment based on benchmark set and other disease nodes outside the benchmark set. Using the statistics such as average, variance, and coefficient of variation in the benchmark set to evaluate multiple methods demonstrates the effectiveness of our approach in the prediction of similar diseases.